Cardiomyocyte contraction is essential for the pumping action of the heart and deteriorates after myocardial damage, either as a consequence of irreversible cardiomyocyte injury or stiffening of the extracellular matrix, a process described as fibrosis. Cell geometry and substrate stiffness not only influence sarcomere...
It is found that a subcellular signaling pathway dysregulated in DCM CMs, clathrin-mediated endocytosis (CME)-dependent signaling, may be recovered by EMP treatment in DCM TPM1-L185F iPSC-CMs, which supports that EMP modulates aspects of CME-signaling, and contributes to restored sarcomere functions.
Daria Plota, H. N. Saleem, K. Lin et al.· Journal of Translational Med...· 0 citations
Mutations in the splice-regulator RBM20 cause heart failure with reduced ejection fraction (HFrEF), typically manifesting as dilated cardiomyopathy (DCM). Mutations at position 634 in the RS-domain cause DCM with (R634L) or without (R634W) left ventricular non-compaction (LVNC). However, the mechanisms underlying pheno...
S. Rebs, F. Sedaghat-Hamedani, E. Kayvanpour et al.· Signal Transduction and Targ...· 0 citations
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