Author

M. T. M. Nemr

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Open access Jul 2026

Design, synthesis, molecular docking and molecular dynamics simulations of pyrazolo[3,4-d]pyrimidine scaffolds as selective COX-2 and CDK2 kinase inhibitors with dual anti-inflammatory and anti-proliferative activities

A new series of pyrazolo[3,4-d]pyrimidine scaffolds, namely, 4a–l, were designed, synthesized, and tested for anti-inflammatory and anti-proliferative activities. Compounds 4f and 4g displayed advanced COX-2 selectivity (SI = 4.95 and 16.22) in comparison to celecoxib (SI = 7.61). In addition, all compounds were evalua...

Sara Y. Ewieda, Laila Ziko, Ahmed Elshewy et al. · RSC Advances · 0 citations

Aug 2026

Design, Synthesis, and Antibacterial Evaluation of Novel Non‐Oxazolidinone Analogues of Linezolid to Investigate the Role of the Oxazolidinone Ring

A new series of non‐oxazolidinone derivatives designed and synthesized as potential analogues of Linezolid exhibited lower antibacterial activity compared to Linezolid and gentamycin, highlighting the crucial role of the oxazolidinone ring in its antibacterial activity.

M. T. M. Nemr, Laila Ziko, Lobna Ghonaim et al. · ChemistrySelect · 0 citations