Preprint
Sep 2026
Optimization of Deep Learning Model for Denoising Dose Profiles in Proton Therapy
This work replaces the standard MSE training objective with a differentiable $\gamma$-index-based loss, extended to native 3D operation, and demonstrates that directly optimising the clinical evaluation metric yields a mean Gamma Passing Rate that is critical for clinical deployment.
J. Jawaid, M. Spezialetti, Gabriele Libardi et al.
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