Pineal region tumors are rare neoplasms that occur in all ages and account for less than 1% of all central nervous system (CNS) tumors in adults but are more frequent in children. Here, we describe a previously unrecognized tumor type of pineal origin characterized by a unique and consistent DNA methylation profile tha...
Helena Bode, A. Suwala, B. Gudenas et al.· Acta Neuropathologica· 0 citations
The tumor microenvironment (TME) of medulloblastoma (MB) influences progression and therapy response, presenting a promising target for therapeutic advances. Prior single-cell analyses have characterized the cellular components of the TME but lack spatial context. To address this, we performed spatial transcriptomic se...
F. Chien, Marina E. Michaud, Mojtaba Bakhtiari et al.· bioRxiv· 5 citations
PURPOSE
No curative options are available for medulloblastoma (MB) in the relapse setting. The tumor microenvironment (TME) influences progression and therapy response, presenting a promising target for therapeutic advances. Prior single-cell analyses have characterized the cellular components of the TME but lack spati...
F. Chien, Marina E. Michaud, Mojtaba Bakhtiari et al.· JCO Precision Oncology· 0 citations
The technical challenges of validating an NGS oncological diagnostic targeted assay for clinical grade accuracy and sensitivity for patient care are presented and how copy number alterations provide a more comprehensive description of the tumors genomic profile are shown.
Y. Yang, V. Vasudevaraja, J. Serrano et al.· medRxiv· 0 citations
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