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#explainable ai Review Open access Sep 2026

Smooth Muscle Cell Plasticity as a Central Determinant of Plaque Stability

This review examines how smooth muscle cell (SMC) fate transitions contribute to the central paradox of atherosclerosis: why thin-cap plaques that only mildly narrow the lumen cause most acute events, whereas many severely stenotic lesions remain stable. We propose that interactions between SMC developmental programmin...

Pei-Yu Chen, M. Simons · 0 citations

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