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Author

M. Shalev-Benami

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2 papers indexed here

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Sep 2026

Phosphate backbone epitranscriptomics: Discovery of natural RNA phosphorothioates and their writer machinery.

Over 150 modifications expand the RNA alphabet, yet all known natural modifications occur on nucleobases or ribose sugars, with none identified on the phosphate backbone. In contrast, phosphorothioates (PSs), in which a non-bridging phosphate oxygen is replaced with sulfur, are central to RNA therapeutics but have neve...

Alexander Maman, Yuko Nobe, K. Fluke et al. · 0 citations
Open access Aug 2026

The structure of the dopamine D3 receptor bound to cariprazine reveals principles for partial agonists with designed pharmacology

The third-generation antipsychotic cariprazine is a low-efficacy partial agonist of the dopamine D3 receptor (D3R). Here, we report the cryo–electron microscopy structure of cariprazine bound to D3R, establishing a framework for understanding ligand recognition in this receptor. We further determine structures of D3R i...

Eliane Hadas Yardeni, D. J. Kiss, Julie Sanchez et al. · 0 citations

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