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Open access Sep 2026

223. Multidomain behavioural profiling in the Flinders Sensitive Line rat and response to escitalopram or a novel butyrylcholinesterase inhibitor: focus on anhedonia

Abstract Background Anhedonia is a core symptom of major depressive disorder (MDD) but is challenging to model and to treat. First-line serotonergic antidepressants, e.g., escitalopram (ESC), often show limited efficacy in certain reward-related domains. Anhedonia is multi-dimensional, encompassing motivational drive,...

N. Olivier, C. Brink, A. Haasbroek-Pheiffer et al. · 0 citations
Open access Sep 2026

437. Development of novel add-on treatment of cognitive dysfunction in schizophrenia

Abstract Background Mental disorders and diseases, such as schizophrenia, are a major health problem that not only inflicts damage to the quality of life of individual patients but also a pose a huge burden of cost for society estimated to be $281 billion in the United States in 2020. Schizophrenia presents a broad ran...

K. Jardemark, J. Bruton, M. Shahid et al. · 0 citations

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