Open access
Sep 2026
Aging is associated with behavioral alterations, lysosomal dysfunction, region-specific inflammation, and glutamatergic synaptic impairments in a Grn knockout mouse model of frontotemporal dementia
Progranulin-related frontotemporal dementia ( GRN -FTD) is an inherited neurodegenerative disorder caused by progranulin (PGRN) deficiency. Although PGRN functions are well characterized and several therapeutic strategies aiming to restore its levels are currently under evaluation, the mechanisms linking PGRN los...
Chiara Bertasini, Maria Italia, Shima Tavakolian Haghighi et al.
· Acta Neuropathologica Commun... · 0 citations