Author

M. Schwab

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#protein folding Open access Oct 2026

Physiologically based pharmacokinetic modeling as a translational tool in forensic toxicology: from pig to human synthetic cannabinoid toxicokinetics using 5F-Cumyl-P7AICA and its major metabolite as a case study.

A PBTK model was developed for 5FC and its primary metabolite N-pentanoic acid in pigs and translated to humans for predicting systemic and tissue-specific exposure and generated exploratory human systemic and tissue exposure predictions.

Omar Zaher, D. Selzer, H. Loer et al. · Archives of Toxicology · 0 citations

Open access Sep 2026

The FAP × CD3 bispecific antibody OMTX305 induces T cell–mediated antitumor effects in patient-derived ex vivo models of solid tumors

Within solid tumors, stromal barriers and immune exclusion limit the success of immunotherapies. Thus, novel therapeutic approaches are required to remodel the tumor-supportive microenvironment and enhance therapeutic responses. We developed a bispecific, trivalent Fab-eIg T cell engager (OMTX305) targeting fibroblast...

Julia Thiel, Jan A. Schlegel, Chun-Guang Liang et al. · Science Advances · 1 citation

Review Open access Aug 2026

Clinical Functional Assignment of TPMT and NUDT15 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel

The work presented here includes the first designation of decreased function alleles for both TPMT and NUDT15, reflecting new clinical data that demonstrate partial loss of enzymatic activity and reduced dose tolerance.

Bailey M. Tibben, Maud Maillard, Victoria M. Pratt et al. · Clinical pharmacology and th... · 0 citations