Author

M. Schmitz

2 papers indexed here

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Open access Sep 2026

Antibody-TLR3 agonist-conjugates program the tumor microenvironment and induce immune responses leading to tumor regression in experimental EGFRvIII-positive glioma.

It is revealed that RICIA is internalized by glioma cells via EGFRvIII-mediated endocytosis and induces a TLR3-dependent type I interferon response.

Alexander Hagstotz, Isabell Schau, Michael Seifert et al. · Biomedicine & pharmacotherap... · 0 citations

Open access Aug 2026

Preclinical evaluation of homodimeric FAPI target modules for UniCAR-mediated targeting of FAP-expressing tumor and stromal cells

Abstract Due to its overexpression in the tumor microenvironment of most solid malignancies, fibroblast activation protein (FAP) has emerged as an ideal target for (immuno)theranostic applications. The clinically tested UniCAR system represents a promising adapter CAR T-cell approach, in which CAR T-cell activity is re...

Hugo Boutier, Simona Mattiussi, L. Loureiro et al. · Oncoimmunology · 1 citation