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M. Schlierf

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#protein folding Open access Oct 2026

Complex folding kinetics of multi-domain proteins disentangled with periodic forces by magnetic tweezers

Force spectroscopy yields direct access to the interplay between free energy and transition kinetics of proteins and nucleic acids. Yet, complex molecules such as multi-domain proteins exhibit multiple intermediates during unfolding and refolding with different or similar stabilities and kinetics ranging from milliseco...

C. A. Quintana-Cataño, Andreas Hartmann, M. Schlierf · 0 citations
Open access Sep 2026

Nucleoid compaction during antibiotic stress excludes the SOS regulator LexA

The bacterial SOS response promotes DNA repair, survival, and mutagenesis under genotoxic stress, especially during sub-lethal antibiotic exposure. This response is regulated by LexA, a transcriptional repressor controlling SOS gene expression, but how LexA coordinates this network as antibiotic stress alters nucleoid...

Pilar Lörzing, Daria Miasoedova, M. Schlierf · 0 citations

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