Open access
Oct 2026
A single anion exchange chromatography step enables scalable, high-yield purification of hepatitis B virus capsid virus-like particles
Introduction Hepatitis B Virus (HBV) causes a significant global health burden. The HBV core (HBc) protein forms the HBV capsid and has a crucial role in the virus replication cycle. When expressed across different platforms, HBc can self-assemble into HBV-capsid-based virus-like particles (VLPs), with a wide range of...
A. Seidler, S. Ambike, C. Peters et al.
· Frontiers in Microbiology · 0 citations