INTRODUCTION
The prevalence of malnutrition in cancer patients is already high at diagnosis, reaching up to 40%, and tends to increase during treatment, affecting up to 75-80% of patients. To investigate the relationship between nutritional status and clinical outcomes, Progression-Free Survival (PFS) and Overall Survi...
Chiara Paciolla, E. Vitale, L. Maistrello et al.· Clinical Nutrition ESPEN· 0 citations
BACKGROUND
Enfortumab vedotin (EV) has transformed treatment for advanced urothelial carcinoma (aUC), but outcomes vary. Machine learning (ML) with explainable artificial intelligence (XAI) may improve survival prediction.
METHODS
Data from 544 aUC patients receiving EV after platinum chemotherapy and immunotherapy (...
K. Sridharan, O. Fiala, G. Sivaramakrishnan et al.· Expert Opinion on Biological...· 0 citations
Beyond the attractive potential to surrogate the tumor tissue testing, to overcome the cancer spatial and temporal heterogeneity, and to monitor the tumor mutational profile over time, accurately detecting all clinically relevant BRCA genetic variants and epigenetic modifications using LB remains technically challengin...
L. Incorvaia, V. Gristina, F. Pepe et al.· ESMO Open· 0 citations
Preliminary, hypothesis-generating findings suggest ML may predict EV-related toxicities, but single train-test split, small event counts, and lack of external validation preclude clinical use.
K. Sridharan, Mattia Alberto Di Civita, G. Sivaramakrishnan et al.· Expert Review of Anticancer...· 0 citations
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