Author

M. S. Luijsterburg

3 papers indexed here

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Open access Oct 2026

Chemogenetic ubiquitin E1 inhibitor TAK-243 CRISPR screen uncovers HAPSTR1/HUWE1 axis in chromatin proteostasis and cell cycle control

In this study, we sought to comprehensively map ubiquitin signaling networks at the crossroads of cellular proliferation and proteostasis, both crucial in cancer. Genome-wide CRISPR knockout screening in the presence of the ubiquitin E1 inhibitor TAK-243 identified 239 genes whose ablation sensitizes cells to ubiquitin...

N. V. van Overbeek, L. Clijsters, M. Wirth et al. · Science Advances · 0 citations

Open access Sep 2026

Helicase-deficient TFIIH causes severe disease features via persistent DNA excision without damage removal

Nucleotide excision repair (NER) removes helix-distorting DNA lesions through the ten-subunit TFIIH complex, whose XPB and XPD translocase/helicase activities unwind DNA to enable damage verification and subsequent endonucleolytic DNA incisions. While most XPD mutations cause xeroderma pigmentosum, specific helicase-de...

David Häckes, A. Theil, Geunhee Kim et al. · bioRxiv · 0 citations

Open access Aug 2026

Sam68 stimulates polymerase theta-mediated end-joining by suppressing poison exon inclusion in Polq mRNA

It is demonstrated that Sam68 is required for proper expression of Polq, the gene encoding polymerase theta (Polθ), the central factor in TMEJ; loss of Sam68 results in reduced TMEJ at CRISPR-induced DSBs.

Marloes D. van Wezel, H. Kool, D. van den Heuvel et al. · Nucleic Acids Research · 0 citations