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Author

M. S. Gold

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Open access Sep 2026

Myotonic Muscle Activity Drives a Persistent Pain State Responsive to NaV1.8-directed Analgesics.

Pain is a common and disabling feature of myotonic disorders, yet its biological basis remains poorly understood and no targeted analgesic therapies currently exist. Here, we demonstrate that skeletal muscle hyperexcitability is sufficient to initiate a persistent pain state independent of inflammation, nerve injury, o...

Tyler S. Nelson, Aida Calderon-Rivera, Heather N. Allen et al. · 1 citation · ⚡1

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