Virus-specific enhancement of the expression of CTLA-4 in T cells from target organs during early and late stages of PRRSV-1 infection with strains of different virulence.
The pathogenesis of the immune dysregulation in porcine reproductive and respiratory syndrome (PRRS) virus (PRRSV) infection is not fully understood yet. In this context, immune checkpoints have been identified as pivotal regulators of inflammatory and immune responses. This study evaluated the expression of CTLA-4 at...