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Imaging subtypes reveal distinct biological substrates and disability profiles in multiple sclerosis.
Multiple sclerosis is characterized by marked biological heterogeneity that is only partly captured by conventional clinical phenotypes and age-at-onset categories. MRI can detect focal lesions, diffuse microstructural damage and atrophy, but these measures are usually considered separately. We therefore aimed to use S...
Pediatric multiple sclerosis: a diagnostic overview and the importance of early identification.
INTRODUCTION Pediatric-onset multiple sclerosis (POMS) is uncommon but clinically relevant, as inflammatory demyelination occurs during brain maturation. Compared with adult-onset MS, POMS is characterized by higher early relapse rate and MRI inflammatory activity, better recovery from individual relapses, yet disabili...