Author

M. Portero-Otín

3 papers indexed here

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Open access Sep 2026

Pharmacological modulation with the LXR agonist T0901317 attenuates motor pathology in the SOD1G93A mouse model of ALS

Dysregulation of cholesterol metabolism and neuroinflammation are critical drivers of Amyotrophic Lateral Sclerosis (ALS) pathology. Liver X receptors (LXRs) are master regulators of cholesterol homeostasis and immune responses. Here, we evaluated the therapeutic potential of chronic pharmacological modulation using th...

Luis C. Fernández-Beltrán, Irene García-Toledo, Karen Javaloyes García et al. · Neurotherapeutics · 0 citations

Open access Sep 2026

A sphingomyelin-cholesterol complex regulates TLR4 activation in microglia

It is shown that LPS increases cholesterol uptake and mobilization, whereas inhibition of intracellular cholesterol trafficking or the plasma membrane-to-ER cholesterol transporter Aster attenuates inflammatory responses, establishing sphingolipid-dependent cholesterol accessibility as a key regulatory layer controllin...

C. Antón-Barros, Beatriz Villarejo-Zori, Sara Carmona-Lorenzo et al. · bioRxiv · 0 citations

Open access Jul 2026

Antisense oligonucleotides treatment uncovers differences in the modulation of dysregulated intracellular pathways in Spinal Muscular Atrophy motoneurons

Observations indicate that nusinersen-like ASO treatment might be insufficient to counteract the full spectrum of intracellular alterations occurring in SMN-reduced MNs, and supplementary compounds targeting these unrecovered pathways might supply additional protective effects on degenerating MNs.

María P. Miralles, Isabel Gimenez-Fernandez, María Beltran et al. · Cell Death and Disease · 0 citations