Author

M. P. Witter

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Open access Aug 2026

Mechanisms of resilience to autosomal dominant Alzheimer’s disease via oligogenic modulation of rare variants in the entorhinal cortex

Two PSEN1 E280A carriers have presented extreme protection against autosomal dominant Alzheimer’s disease (ADAD), with over two decades of delay for dementia onset. One of them, a male heterozygous for the RELN-COLBOS protective variant showed increased neuronal density in the entorhinal cortex 1. We conducted a deep p...

Yassir El-Amri, N. Villalba-Moreno, Julia A. Urban et al. · bioRxiv · 0 citations

Open access Aug 2026

Transcriptomic characteristics along the longitudinal axis of the hippocampus and medial entorhinal cortex across species

A comprehensive molecular atlas of HPC and MEC in five species is generated, standardizing the dorsoventral axis for cross-species comparison and revealing both conserved and species-specific dorsoventral programs underlying brain function and evolution.

Sihui Cheng, Qi-Run Wang, Ye Feng et al. · bioRxiv · 0 citations