M. P. Reeve

Clinical history shapes the predictive value of polygenic risk

For most diseases, whether PRS improves prediction beyond clinical data remains unknown, as existing evidence is concentrated in a handful of conditions with established risk models. Using 900,000 participants from UK Biobank and FinnGen, we developed and validated models for predicting 150 diseases and all-cause morta...

Population-scale immune multiome atlas reveals regulatory disease mechanisms.