Enzymatic Lipid Oxygenation and Ferroptosis Resistance: A Critical Evaluation of the Lipid Antioxidant Barrier Hypothesis
This review synthesizes the emerging paradigm of directed lipid oxygenation as a regulated, adaptive mechanism that may function as a physiologically regulated lipid antioxidant barrier for ferroptosis, and examines how enzymatic lipid oxygenation generates bioactive oxylipins that activate cytoprotective transcription...