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M. Obushak

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Open access 2026

Diethyl 4-(1-aryl-3-(ethoxycarbonyl)-1H-pyrazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylates as possible antitubercular agents: Synthesis, ADME profiling, and in silico screening through molecular docking

A method for the synthesis of diethyl 4-(1-aryl-3-(ethoxycarbonyl)-1H-pyrazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylates was developed via a modified Hantzsch three-component cyclocondensation. High structural similarity to known lead antitubercular agents was found using Tanimoto coefficients. In silico...

Y. Nefedov, M. Obushak, Vasyl Matiychuk · 0 citations

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