M. Mugale

Bergenin attenuates diabetic cardiomyopathy by inhibiting oxidative stress and ferroptosis through modulation of the YAP signaling axis.

AIMS Diabetes mellitus-associated cardiac dysfunction arises from metabolic imbalance, oxidative stress, inflammation, maladaptive remodeling, and impaired cardiac performance. Bergenin (BER), a naturally occurring small molecule with antioxidant, anti-inflammatory, and metabolic regulatory properties, has shown therap...

A standardized fraction of Cajanus scarabaeoides attenuates diabetic nephropathy via antiglycation, anti-inflammatory, and anti-fibrotic mechanisms.

Concurrent upregulation of autophagic flux and induction of the SQSTM1/p62-VCAM-1 axis deter radiosensitivity of triple-negative breast cancer cells

A constitutively high basal level of autophagy is demonstrated in TNBC cells, which might contribute to their relatively lower sensitivity to radiation-induced cell death and to the driving forces in acquiring radioresistance.