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Author

M. Mariani

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Open access Aug 2026

Time-dependent prognostic impact of tumor grade in stage I-III breast cancers

Background Breast cancer (BC) mortality risk extends over decades; yet, the temporal prognostic patterns of histological grade across subtypes and stages remain unclear. Patients and methods Women with stage I-III BC diagnosed between 2000 and 2018 were identified from Surveillance, Epidemiology, and End Results regist...

M. Mariani, M. Ochocki, G. Bianchini et al. · 0 citations
Jul 2026

Abstract A024: FastBindRank, a novel, scalable method for high-fidelity virtual screening of ultra-large chemical libraries idendtifies novel HDAC11 inhibitors

FastBindRank is presented, a distillation-based framework that transfers the predictive power of a high-accuracy structure-based model (Boltz-2) into a computationally efficient sequence-based surrogate and can identify functionally active novel compounds from ultra-large virtual screening.

J. Dai, Yueyue Wang, N. Shan et al. · 0 citations
Open access Jul 2026

Distillation enables scalable high-fidelity virtual screening across ultra-large chemical libraries

Distillation is established as a practical strategy for scalable, high-fidelity virtual screening of ultra-large chemical libraries by transferring the predictive power of the structure-based model Boltz-2 into an efficient sequence-based surrogate, FastBindRank.

J. Dai, Yueyue Wang, N. Shan et al. · 0 citations

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