Background People with Severe Mental Illness (SMI) experience a 15–20-year shorter life expectancy than the general population, with increased premature deaths from somatic illnesses, and twice to more than four times the general population’s all-cause mortality risk. Integrated care could potentially improve these out...
Owen Taylor, S. Loubière, R. E. Nielsen et al.· Open Research Europe· 0 citations
AIMS
This study investigates whether the melatonin (MLT) system modulates the behavioral, neurophysiological and neurochemical effects of fecal microbiota transplantation (FMT) from individuals with schizophrenia (SCZ), highlighting the role of the tryptophan (Trp) to MLT and kynurenine (Kyn) pathways.
MATERIALS AND...
B. Barzon, A. Shkodra, M. D'Incalci et al.· Life Science· 0 citations
BACKGROUND
Impaired cognitive functioning is a severe symptom in major depressive disorder (MDD). Recent evidence suggests it may be a central characteristic in its treatment resistant form (TRD), potentially constituting a clinical marker for treatment resistance and a target amenable to intervention. To date, cogniti...
V. T. Wahner, T. Lange, Inga Stonner et al.· Journal of Affective Disorde...· 0 citations
Investigating the interplay between Trp metabolism, inflammation, and gut microbiota in modulating cognitive and metabolic phenotypes in schizophrenia suggests that dysregulated Trp metabolism acts as a translational bridge connecting genetic background, metabolic status, and microbiota-derived signals to SCZ pathophys...
B. Barzon, A. Shkodra, S. Nasini et al.· International Journal of Neu...· 0 citations
Abstract Background Major depressive disorder (MDD) is the most common mental disorder and is associated with substantial functional impairment, socioeconomic costs and reduced quality of life. One third of patients presents treatment-resistant depression (TRD), a major clinical challenge that highly contributes to the...
C. Pisanu, Y. Xiong, D. Congiu et al.· International Journal of Neu...· 0 citations
This study suggests that BD patients present significant differences in gene expression patterns compared to healthy controls, and pathway analyses suggest that protein misfolding and endoplasmic reticulum alterations could be implicated in the pathophysiology of BD, while response to lithium might be related to modula...
A. Squassina, M. Manchia, C. Chillotti et al.· International Journal of Neu...· 0 citations
Key mechanisms identified include Nrf2/HO-1-driven oxidative stress and neuronal apoptosis, disruption of calcium signalling and synaptic plasticity via CREB phosphorylation deficits, epigenetic suppression of brain-derived neurotrophic factor via promoter hypermethylation, interference with thyroid hormone bioavailabi...
M. Lastretti, Andrea Faa, Monica Piras et al.· Environments· 0 citations
Bipolar disorder’s genetic architecture appears hierarchical—a general liability resolving into dimensions of course and comorbidity, beyond subtypes, beyond subtypes.
Tracey van der Veen, M. Tesfaye, J. M. K. Yang et al.· Research Square· 0 citations
Eotional reliance on AI represents an emerging clinical phenomenon with addiction-like features requiring specific diagnostic frameworks, evidence-based interventions, and ethical design guidelines and future research should prioritize longitudinal studies examining developmental impacts and neurobiological investigati...
M. Lastretti, M. Manchia, Matteo Fraschini et al.· Psychiatry International· 0 citations
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