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Author

M. Majidinia

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2 papers indexed here

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Open access Sep 2026

Diosgenin enhances 5-fluorouracil sensitivity in drug-resistant colorectal cancer cells via inhibition of ATR/Chk1-mediated DNA damage response.

BACKGROUND AND OBJECTIVE Drug resistance to 5-fluorouracil (5-FU) is one of the major challenges in the treatment of colorectal cancer, which is largely associated with the activation of DNA damage response (DDR) pathways, especially the ATR-CHK1 axis, and increased activity of drug efflux pumps. The aim of this study...

Bita Azizzadeh, A. Mihanfar, M. Majidinia · 0 citations
Review Open access Aug 2026

The Multifaceted Role of MAPK/ERK Signaling Pathways in Cancer Drug Resistance: An Update

Cancer is among the leading causes of global mortality. In addition to uncontrolled proliferation, cancer cells activate survival pathways that favor the expansion of malignant cell populations. A critical component of these survival mechanisms is drug resistance, which often prevents the achievement of optimal therape...

Mehran Molavand, Amir Valizadeh, M. Majidinia et al. · 0 citations

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