Author

M. MacCoss

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Sep 2026

Prioritizing Peptides for Targeted Mass Spectrometry Experiments Using Deep Learning.

One critical step in any targeted mass spectrometry experiment is selecting, from each protein of interest, a small number of peptides that respond well in the mass spectrometer and can serve as reliable proxies for protein quantification. Existing methods select target peptides either by relying on prior empirical mea...

Shreyash Sonthalia, Bo Wen, Priank Dasgupta et al. · Journal of Proteome Research · 0 citations

Open access Jul 2026

Hepatic huntingtin loss drives an acute phase response and liver injury in multiple mouse models

Multiple therapeutic strategies are being developed to slow Huntington’s disease (HD) progression through targeted reduction of huntingtin (HTT) protein or mRNA. Despite HTT’s discovery over 30 years ago, its cellular functions remain incompletely understood, and the long-term consequences of HTT-lowering therapies rem...

Colby L. Samstag, Robert M. Bragg, Kelsie Neumann et al. · bioRxiv · 0 citations