The establishment of the body plan during gastrulation represents a hallmark of animal life. It emerges from the interplay of gene-regulatory programs and positional cues, yet how these signals are integrated post-transcriptionally remains largely unexplored. Here, we combine the scalability of mouse gastruloids with a...
D. Taborsky, Fabiola Valdivia-Francia, Pablo Serrano et al.· Nature Communications· 0 citations
ABSTRACT Cell state, growth, and mechanics are tightly connected properties underpinned by fundamental biological processes. Yet methods to quantify them simultaneously under physiologically relevant conditions, at resolutions sufficient to follow (sub)cellular processes, are still lacking. In particular, the correlati...
Ilaria Incaviglia, Giulia E. M. Ammirati, S. Herzog et al.· Advancement of science· 0 citations
Clinical translation of T cell bispecific (TCB) therapies in solid tumors is hindered by the immunosuppressive tumor microenvironment and intratumoral heterogeneity, features poorly captured by standard preclinical models. We applied an integrated translational framework, combining humanized mouse models, a patient-d...
Sabine Wilson, Abraham Silva, M. Serrano-Serrano et al.· npj Precision Oncology· 0 citations
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