Author

M. Linne

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Open access Sep 2026

Biophysically inspired mean-field model of neuronal populations driven by ion-exchange mechanisms

Whole-brain simulations are a valuable tool for gaining insight into the multiscale processes that regulate brain activity. Due to the complexity of the brain, it is impractical to include all microscopic details in a simulation. Hence, researchers often simulate the brain as a network of coupled neural masses, each de...

G. Rabuffo, Abhirup Bandyopadhyay, Carmela Calabrese et al. · eLife · 0 citations

Open access Oct 2026

Network-level restoration of impaired memory function in early Alzheimer’s disease via GluN2B modulation: insights from a hippocampal CA1–CA3 model

Memory storage and recall are essential tasks for the healthy function of the hippocampus, adversely affected by neurodegenerative diseases, such as Alzheimer’s Disease (AD). Pathological levels of amyloid-β peptide (Aβ), found already in early-stage AD, can disrupt the NMDAR-dependent plasticity at hippocampal network...

Fabio Librizzi, Saana Seppälä, M. Linne et al. · Frontiers in Computational N... · 0 citations