Open access
Sep 2026
JP-1302 inhibits RNA polymerase I transcription and induces nucleolar stress in cancer cell lines
Cancer cells upregulate ribosomal RNA (rRNA) synthesis to sustain the elevated ribosome production that fuels rapid proliferation, creating a dependency that renders RNA polymerase I (Pol I) transcription a pharmacological vulnerability. JP-1302 is a blood-brain barrier-penetrant 9-anilinoacridine derivative developed...
Sheetanshu Saproo, S. Papadaki, Johana Fernandez-Martinez et al.
· Cell Death Discovery · 0 citations