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M. Leotta

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Open access Oct 2026

CO-78 | REAL-WORLD MANAGEMENT OF ACQUIRED HEMOPHILIA A: FOCUS ON RECOMBINANT PORCINE FVIII AS FIRST-LINE HEMOSTATIC TREATMENT AND LONG-TERM OUTCOMES

Background. Acquired Hemophilia A (AHFA) is a rare bleeding disorder caused by the development of neutralizing autoantibodies against endogenous coagulation factor VIII (FVIII). The clinical presentation is often characterized by sudden, severe subcutaneous and mucosal hemorrhages. Management is inherently complex: it...

M. Leotta · 0 citations
Open access Oct 2026

CO-75 | ASSAY DISCREPANCY IN HEMOPHILIA A CARRIERS: CLINICAL AND GENETIC INSIGHTS

Background. Hemophilia A (HA) is an X-linked coagulopathy caused by F8 gene mutations. While research often focuses on males, female carriers frequently experience hemorrhagic diathesis due to skewed X-chromosome inactivation (lyonization). A critical diagnostic challenge is "assay discrepancy," where Factor VIII activ...

M. Leotta · 0 citations

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