Author

M. Legrand

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Review Open access Sep 2026

Lung‐Cardiovascular Interactions and Derangements in ARDS

ABSTRACT The acute respiratory distress syndrome (ARDS) is fundamentally characterized by alveolar injury, leading to lung edema, severe hypoxemia, and poorly compliant lungs. Alveolar and cardiovascular pathology are deeply intertwined in the syndrome, which can be marked by clinical cardiac, pulmonary, and systemic v...

P. A. Sanchez, Connor G. O'Brien, M. Legrand et al. · Comprehensive Physiology · 0 citations

Open access Aug 2026

Plasma proteomics defines two reproducible subphenotypes of sepsis-associated acute kidney injury with distinct outcomes

Sepsis is the leading cause of acute kidney injury in critically ill patients, and this complication carries a high risk of death. The biology underlying it varies between patients, which may explain why treatments have not succeeded. Here we show, using an ensemble method that groups patients by patterns across hundre...

M. Legrand, H. Nguyen, C. Calfee et al. · Nature Communications · 0 citations