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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

M. Laakso

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Open access Oct 2026

Untargeted metabolomics identifies novel metabolites and pathways in Finnish men with heart failure

Early predictors of heart failure (HF) remain poorly defined. We measured plasma metabolites in a population-based Finnish cohort to identify metabolites that independently predict incident HF. We also performed an exploratory analysis of whether selected metabolites improved discrimination beyond traditional clinica...

Lilian Fernandes Silva, J. Vangipurapu, Anniina Oravilahti et al. · 0 citations
Open access Aug 2026

Integrated Analysis of Skeletal Muscle Transcriptional Networks Characterizes Dysregulation in Pathways and Trait-Associated Regulatory Regions in Type 2 Diabetes

Together, the results reveal dysregulation in pathways in muscle tissue from individuals with diabetes, identify candidate drivers, and connect the genomic drivers of this dysregulation across type 2 diabetes and related metabolic traits.

A. Maddox, Nandini Manickam, Peter Orchard et al. · 0 citations
Open access Aug 2026

Erosion of regenerative regulation: age-associated shifts in the skeletal muscle fiber epigenome and transcriptome

Together, these findings identify an age-associated regulatory shift, largely invisible in matched transcriptomic data, characterized by closing chromatin which reduces accessibility to hormone receptor binding sites and enhancer regions in the muscle fiber epigenome.

Keagan G. Moo, Peter Orchard, Arushi Varshney et al. · 0 citations

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