Author

Marcus Krueger

3 papers indexed here

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Open access Sep 2026

Role of Nuclear SUMO-Targeted Ubiquitin Ligase Uls2 (Slx5-Slx8) in Quality Control of Cytosolic Proteins

The interplay between the posttranslational modifiers SUMO and ubiquitin mediates the degradation of proteins. This crosstalk is conveyed by SUMO-targeted ubiquitin ligases (STUbLs). The best-studied STUbL in Saccharomyces cerevisiae is the heterodimer Slx5-Slx8 (Uls2). Uls2 mainly resides in the nucleus and is involve...

Friederike Profe-Austermann, Lennard-Maximilian Döring, L. Schmidt et al. · Biomolecules · 0 citations

Open access Sep 2026

Spatial proteomics identifies FXYD6 as a dual-site protein of neuromuscular junction in the diaphragm

Morphological studies of the diaphragm have provided a detailed view of its architecture, which consists of parallel skeletal muscle fibers and a central ring of neuronal innervation that includes neuromuscular junction (NMJ) units. NMJs are disease-vulnerable synapses; thus, analysis of the NMJ is essential to underst...

Nitin Eapen, L. Schmidt, M. Saynisch et al. · Communications Biology · 0 citations

Open access Aug 2026

Antisense oligonucleotide selection scheme for rare Duchenne muscular dystrophy mutations: Application to DMD exon 16 skipping

Over the last decades, antisense oligonucleotides (AONs) have emerged as powerful tools to modulate alternative splicing, allowing exclusion of a specific exon from a target mRNA to bypass mutations or restore the reading frame, enabling production of a functional protein. In Duchenne muscular dystrophy (DMD), a lethal...

Marine Geoffroy-Guiraud, C. Beley, Stephany Campuzano et al. · Molecular Therapy: Nucleic A... · 0 citations