Author

M. Koptyra

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Open access Sep 2026

Proteogenomic analysis of pediatric and AYA high-grade glioma reveals age-dependent biology, female-male differences, and kinase targets.

High-grade gliomas (HGGs) in children and adolescents and young adults (AYA) exhibit distinct biology across the neurodevelopmental spectrum. To dissect tumor-intrinsic molecular characteristics independent of developmental variation, we perform comprehensive proteogenomic analyses of tumors from 112 HGG patients aged...

N. Tignor, M. Koptyra, Shrabanti Chowdhury et al. · Cell Reports Medicine · 0 citations

Open access Aug 2026

A patient-derived tumoroid platform for NF1 low-grade glioma shows myeloid evolution and shifting metabolic dependencies during in vitro culturing

About 10–15% of individuals with Neurofibromatosis Type 1 develop a low-grade glioma (LGG) within the optic pathway, and an additional 3–5% of individuals develop LGG outside of the optic pathway. In recent years molecular analysis has greatly enhanced our understanding of what drives these NF1 LGG; however, to date...

David R. Beale, Isabella A DiStefano, Stephanie N. Brosius et al. · Acta Neuropathologica Commun... · 0 citations