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Open access Sep 2026

Short term ex vivo graft conditioning with venetoclax, fluticasone propionate, and IL-2 reduces graft versus host disease in mouse allogeneic hematopoietic cell transplantation

Hematopoietic cell transplantation is a curative therapy for certain hematologic malignancies but is limited in use due to post-transplant complications such as graft-versus-host disease (GVHD), wherein donor cells mount an immune response against host tissues. GVHD is a major cause of post-transplant mortality, inspir...

L. A. Ayala, Alizeh H. Ahmedani, Cui-Wen Zhou et al. · 0 citations
Open access Aug 2026

TREM2 plays a critical role in innate immune defense against acute Toxoplasma gondii infection by promoting macrophage antimicrobial activities

A critical role is demonstrated for TREM2 in the early antimicrobial immune response to T. gondii infection by limiting parasite expansion, dissemination, and pathological inflammation in the infected host.

Hannah Z. Debray, Dillon Cheng, L. A. Ayala et al. · 0 citations

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