Circadian modulation of aperiodic background and oscillatory activity as a biomarker of seizure burden in Lennox-Gastaut syndrome.
OBJECTIVE Lennox-Gastaut syndrome (LGS) is a severe childhood onset epilepsy marked by drug-resistant seizures and generalized electroencephalographic abnormalities. Because patient-reported seizures are often unreliable, objective biomarkers are needed. This study investigates circadian modulation of aperiodic and osc...