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M. Heilig

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Open access Oct 2026

Altered GABAB receptor sensitivity in heavy drinkers indexed using a TMS-based biomarker: a randomized controlled experimental medicine trial

Metabotropic γ-aminobutyric acid type B receptors (GABABRs) are implicated in alcohol use disorder (AUD) and represent a promising therapeutic target. However, robust biomarkers of GABABRs target engagement and sensitivity in humans are lacking. We examined transcranial magnetic stimulation (TMS)–derived cortical inhib...

C. Montemitro, Daphne Donahue, Andrea Costumati et al. · 0 citations
Open access Sep 2026

482. Altered GABAb receptor–mediated cortical inhibition in heavy alcohol use: evidence from a pharmaco-TMS study using baclofen

Dose- and group-dependent modulation of GABAbR-mediated cortical inhibition by baclofen is demonstrated, and LICI emerges as a sensitive, non-invasive biomarker of GABAbR function and pharmacodynamic target engagement, with potential utility for stratifying neurobiological heterogeneity and informing the development of...

C. Montemitro, I. Perini, M. Heilig · 0 citations
Open access Sep 2026

Shared Latent Decision Strategies Underlie Reward-Guided Behavior Across Species

A conserved latent reward-learning strategy is identified in mice and humans characterized by the greatest feedback sensitivity, reward efficiency, and adaptation after reversal, defining a translational framework for studying how adaptive decision-making is shaped by task experience, stress, affective processes, and n...

Zahra Rostami, Hadi Choubdar Parvin, E. Iyer et al. · 0 citations

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