Metabotropic γ-aminobutyric acid type B receptors (GABABRs) are implicated in alcohol use disorder (AUD) and represent a promising therapeutic target. However, robust biomarkers of GABABRs target engagement and sensitivity in humans are lacking. We examined transcranial magnetic stimulation (TMS)–derived cortical inhib...
C. Montemitro, Daphne Donahue, Andrea Costumati et al.· Translational Psychiatry· 0 citations
Dose- and group-dependent modulation of GABAbR-mediated cortical inhibition by baclofen is demonstrated, and LICI emerges as a sensitive, non-invasive biomarker of GABAbR function and pharmacodynamic target engagement, with potential utility for stratifying neurobiological heterogeneity and informing the development of...
C. Montemitro, I. Perini, M. Heilig· International Journal of Neu...· 0 citations
A conserved latent reward-learning strategy is identified in mice and humans characterized by the greatest feedback sensitivity, reward efficiency, and adaptation after reversal, defining a translational framework for studying how adaptive decision-making is shaped by task experience, stress, affective processes, and n...
Zahra Rostami, Hadi Choubdar Parvin, E. Iyer et al.· bioRxiv· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.