Background Intratumoral heterogeneity (ITH) is thought to contribute to tumour evolution and treatment resistance but its biological and clinical significance in localised head and neck squamous-cell carcinoma (HNSCC) remains incompletely understood. Patients and methods In the prospective SCANDARE study, we analysed 8...
V. Heurtier, G. Marret, C. Lamy et al.· ESMO Open· 0 citations
BACKGROUND
Pembrolizumab-lenvatinib (P/L) is a standard option for patients with advanced or metastatic endometrial cancer (a/m EC) progressing after platinum-based chemotherapy, based on the KEYNOTE-775 trial. However, concerns remain regarding its real-world applicability, particularly in older, frailer patients and...
D. B. Roufai, L. Mansi, M. H. Diallo et al.· ESMO Open· 0 citations
Background Extensive-disease small-cell lung cancer (ED-SCLC) is an aggressive disease with limited effective therapeutic options. Clinical trials suggest an additive effect of chemotherapy and immunotherapy in SCLC, although the magnitude of benefit seems to be limited. Considering the prolonged peripheral persistence...
E. Gobbini, M. H. Diallo, C. Clément-Duchêne et al.· ESMO Open· 0 citations
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