Mycobacterium tuberculosis (Mtb) secretes antigenic proteins that drive protective T cell responses, yet how Mtb intracellular localization affects the trafficking and spatiotemporal distribution of mycobacterial antigens in macrophages remains elusive. Here, we developed a split fluorescent protein reporter to monitor...
Chak-Hon Luk, Tania Auchynnikava, A. Fearns et al.· bioRxiv· 0 citations
A dual-fluorophore Mtb reporter system is developed that enables high-content, live-cell imaging of Mtb gene expression with high spatial and temporal resolution and reveals underappreciated heterogeneity in Mtb gene expression dynamics in vitro and in vivo.
Beren Aylan, Laure Botella, Pierre Santucci et al.· Cell Reports Methods· 0 citations
DFCP1 mediates concentration of the ER-associated lipid transport machinery at damaged lysosomes to promote their sealing in response to Ca2+ flux and PIK3C3 activation, and concludes that DFCP1 compromises cellular resistance to vacuolar damage induced by Listeria monocytogenes.
Maja Radulovic, S. Pust, Athanasios Kournoutis et al.· Nature Cell Biology· 2 citations
It is shown that LRRK2 G2019S has an effect during lysosomal damage through kinase-dependent and kinase-independent mechanisms, and isogenic induced pluripotent stem cells from patients carrying the LRRK2 G2019S variant confirmed that LRRK2 G2019S macrophages are more susceptible to cell death in a kinase-independent m...
Rebecca Morrison, Simeon R. Mihaylov, Chak-Hon Luk et al.· Journal of Cell Science· 1 citation
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