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M. Gruebele

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#protein folding Sep 2026

Conformational Landscape of a Marginally Disordered Protein HYPK and its Charge-Variant Mutant in the Context of Folded Domains

Intrinsically disordered proteins (IDPs) can have varying proportions of disordered and structured regions, and various fractions of amino acids promoting these regions. This raises the possibility that some IDPs may behave as marginal proteins, exhibiting properties of both disordered and folded states. HYPK is one...

Kari Gaalswyk, M. Gruebele, Kingshuk Ghosh · 0 citations

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