Pancreatic ductal adenocarcinoma (PDAC) remains among the most lethal malignancies, with limited survival despite advances in systemic therapy. Activating KRAS mutations, present in approximately 90% of PDACs, contribute to tumor progression in part through regulation of c-Myc. Tumor Treating Fields (TTFields) therap...
H. Fishman, Y. E. Mutlak, L. Lifshitz et al.· Cancer Research· 0 citations
The results define cis-PTase as a master regulator of CNS development and function and establish that its monoallelic debilitating variants cause a novel congenital disorder of glycosylation associated with aberrant levels of neuronal proteins and lipids.
Afitz Da Silva, Merrick S. Fallah, Samuel Boris Tene Tadoum et al.· Brain : a journal of neurolo...· 0 citations
These findings further support biallelic loss of function variants in DAND5 autosomal recessive laterality defects and suggest DAND5 has recently been suggested as a candidate gene in heterotaxy and CHDs.
O. Chorin, Yoav Bolkier, Uriel Katz et al.· Genes· 0 citations
This fluorescence-based system provides a practical, mechanistically informative, and high-throughput-compatible platform for prenyltransferase inhibitor discovery.
Ruba Yehia, M. Giladi, Y. Haitin· Journal of Enzyme Inhibition...· 0 citations
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