Open access
Jul 2026
Multifunctional-engineered NK cells overcome tumor immunosuppression by combining PD-L1 and HLA-E targeting and endogenous IL15 production
A next-generation NK cell platform using a tri-cistronic retroviral vector that encodes an extracellular PD-1 domain fused to the intracellular portion of NKG2D with the costimulatory molecule 4-1BB and induces de novo PD-L1 expression in otherwise negative tumors is developed.
P. Fiore, Sergio Forcelloni, Lorenzo Moretta et al.
· Signal Transduction and Targ... · 0 citations