M. Garhewal

Development and Evaluation of a Hydroxyurea-loaded Invasome Hydrogel for Enhanced Anti-psoriatic Efficacy and Reduced Systemic Exposure

Design of Quinazoline Dual Inhibitors Targeting Focal Adhesion Kinase and Polo-like Kinase 1 for Metastatic Cancers: QSAR, Pharmacophore Modelling, and Molecular Docking Approaches.

INTRODUCTION FAK and PLK1 are regulators of oncogenic signaling and metastasis, and their coinhibition offers a synergistic anticancer strategy. This study employed computational modeling to design quinazoline-based scaffolds as potential dual FAK-PLK1 inhibitors. METHODS 54 quinazoline derivatives were analyzed usin...

2D-QSAR Modeling of Quinazoline Derivatives as EGFR Inhibitors for Colorectal Cancer

Background: Globally, colorectal cancer represents one of the most common types of cancer, along with being one of the top 10 causes of cancer-related deaths. Epidermal Growth Factor Receptors (EGFRs) are a major target for colorectal cancer, and quinazoline derivatives have shown anticancer activity as EGFR inhibitors...