M. Gandal

Autism genes converge on three functional programs organized by neuronal subclass, developmental timing, and cortical patterning

Human genetic risk for major depressive disorder implicates motor cortex PVALB⁺ inhibitory neurons

Major depressive disorder (MDD) is highly polygenic, but the cellular and anatomical contexts through which inherited risk contributes to disease biology remain incompletely understood. Here we integrated large-scale MDD genome-wide association studies with an adult human brain single-cell discovery atlas and five inde...

Morphogen-guided neocortical organoids with anteroposterior areal identity

This study establishes a straightforward method for generating arealized organoids through short-term early exposure to anterior or posterior morphogens and provides a robust platform for generating neocortical organoids with AP molecular signatures and highlights the importance of modeling NDDs using experimental plat...