Author

M. Elkabets

2 papers indexed here

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Open access Oct 2026

Targeting tumor-selective membrane-associated PCNA enables selective antibody–drug conjugate therapy

ABSTRACT Membrane-associated proliferating cell nuclear antigen (mPCNA) is an attractive tumor-selective antigen for antibody–drug conjugate (ADC) development. We generated a chimeric IgG1 ADC, RC14-MMAE, to exploit three key properties of mPCNA that support its use as an efficient delivery platform. First, flow-cytome...

Muhammad Abu-Ahmad, Nir Miriam Ungar-Malma, A. Naumchik et al. · Oncoimmunology · 0 citations

#protein folding Open access Sep 2026

HSPD1 promotes neuroblastoma by augmenting MYCN expression

It is shown that HSPD1 depletion in MYCN-amplified NB cells led to reduced mitochondrial translation, MYCN expression, and tumorigenesis in vitro and in vivo and establishes HSPD1 as a promising target for the treatment of MYCN-amplified NB.

Shatha S. Alassam, Dinesh Babu Manikandan, Hila Ben-David et al. · bioRxiv · 0 citations