Author

M. Donia

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Open access Aug 2026

Crosstalk between S-nitrosylation and glycation defines a metabolic vulnerability in liver and renal cancers

Metabolic reprogramming is a defining feature of cancer; however, how it contributes to therapeutic resistance remains incompletely understood. Here we show that loss of aldo-ketoreductase 1A1 (AKR1A1) in renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC) disrupts terminal glycolytic flux and lactate product...

Chiara Pecorari, Mojca Bratina, Evelyn Gonzalez et al. · Nature Communications · 1 citation

Open access Sep 2026

Receptor-defined targeting of a genomically unique melanoma-enriched noncanonical antigen

Effective T cell–based immunotherapies require functional receptors that can be engineered and redeployed to recognize tumor-restricted antigens. Noncanonical peptides arising from transcription outside annotated protein-coding regions expand the antigenic landscape of cancer; however, systematic strategies to biologic...

T. Hulen, M. D. Crowther, Luke Alexander Schuster et al. · Signal Transduction and Targ... · 0 citations