Author

M. Di Palma

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Open access Sep 2026

Structural basis of ligand-selective transcriptional activation in the MerR-family antibiotic resistance regulator AlbA

Multidrug-resistant pathogens demand novel resistance-breaking strategies. The oligoarylamide albicidin and pyrrolobenzodiazepines (PBDs) are potent antibacterials with unrelated scaffolds, yet both are neutralized by albA gene products in many Gram-negatives: AlbA, an albicidin-responsive self-upregulating MerR-family...

M. Di Palma, A. Grinzato, P. Andriollo et al. · bioRxiv · 0 citations

#artificial intelligence Open access Sep 2026

Clinical usability of an explainable AI decision support tool and evaluation of multimodal models in NSCLC

In a large international real-world study of non-small cell lung cancer, a multimodal explainable AI model outperformed established biomarkers for immunotherapy outcome prediction and improved physician decision-making.

A. Prelaj, V. Mišković, Matteo Sacco et al. · Nature Medicine · 1 citation