Urinary tract infections (UTIs), particularly cystitis, are among the most common bacterial infections worldwide, with a disproportionate burden on adult female individuals, who often have recurrence. The discovery of the urobiome, a low microbial biomass community in the urinary tract, has transformed our understandin...
Marleen D. Hekker, Adam J. Bindas, Freya Darling Eriksen et al.· The Lancet Microbe· 0 citations
Background Despite increased recognition of the urinary tract’s diverse resident microbiome (i.e., the urobiome) in postmenopausal women, the roles and functions of these microbes remain largely unknown. Further empirical research is needed to understand the physiology, interactions, and antibiotic resistance evolution...
Freya Darling Eriksen, Marleen D. Hekker, Corné van der Zeeuw et al.· bioRxiv· 1 citation
PhenoRewire, a network-based framework that quantifies how metabolite co-variation is rewired between biological states using untargeted metabolomics data, is developed and applied to an induced pluripotent stem cell (iPSC) urothelial organoid-derived barrier co-cultured with synthetic urobiome communities as a model o...
L. della Vedova, Adam J. Bindas, Mariana Teixeira Dias et al.· bioRxiv· 0 citations
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