Triple-negative breast cancer (TNBC) is an aggressive malignancy with limited therapeutic options and a high risk of relapse and mortality. Consequently, there is a critical need for personalized treatment strategies that reflect the unique biology, clonal architecture, and evolutionary dynamics of individual tumors. H...
P. Victori, Kui Hua, Alecia-Jane Twigger et al.· Cell Reports Medicine· 0 citations
The meninges form the border between the brain and periphery and house a rich network of immune cells. Here we show that gastrointestinal challenges (intracellular or extracellular bacteria and parasites) reshape the nature of CD4+ T cells in the dura mater, the outer meningeal layer, changing the dominant polarization...
Aaron Fleming, Karen Neish, Rafael Di Marco-Barros et al.· Nature Neuroscience· 2 citations
This work assembled 18 human kidney single-cell and single-nucleus RNA-sequencing datasets spanning 232 donors and five major disease contexts into a uniformly processed and computationally integrated Human Kidney Cell Atlas (HKCA).
Konstantinos Stasinos, Han-Chen Wang, A. Predeus et al.· bioRxiv· 0 citations
Spatial transcriptomics maps gene expression at cellular resolution, revealing how cells organize into multicellular niches. Yet computational analyses remain dataset-specific, without a transferable representation of tissue organization that generalizes across datasets, tasks and tissues or predicts how tissues behave...
Sebastian Birk, M. V. Sanian, Amirhossein Vahidi et al.· bioRxiv· 4 citations· ⚡1
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